Protein Modification Reagents
AdipoGen Guanidine thiocyanate
Chemical. CAS 593-84-0. Formula CH5N3 . CHNS. MW 59.07 . 59.09. Guanidine thiocyanate is a powerful, chaotropic agent which is widely used for purification of proteins and nucleic acids. Guanidine thiocyanate is preferred for the purification of RNA because it dissociates the RNA into its nucleic acids and protein forms and is commonly used in the guanidinium thiocyanate-phenol-chloroform extraction method. As one of the strongest protein denaturants, it inactivates nucleases more than twice as fast as Guanidine hydrochloride. It is useful for denaturation and refolding of proteins. At high molarity solutions, Guanidine thiocyanate irreversibly inactivates RNase. Guanidine thiocyanate causes proteins to dissolve readily, thus disintegrating cellular structures.
Medchemexpress LLC Pomalidomide-5'-peg8-c2-cooh | 2138440-78-3 | 98.2% | 697.73 | C32H47N3O14 | 10 MG
Pomalidomide-5'-PEG8-C2-COOH is an E3 ligase ligand-linker conjugate that links a pomalidomide E3 ligase ligand to an eight-unit polyethylene glycol (PEG8) spacer terminated with a two-carbon carboxylic acid. It is intended as a building block for PROTAC synthesis and other E3 ligase recruitment applications.
- Used as a building block for PROTAC synthesis and E3 ligase recruitment studies.
- Conjugate of pomalidomide and a PEG8 linker with a C2 carboxylic acid terminus.
- High purity: 98.2%.
- Molecular weight 697.73 g/mol; formula C32H47N3O14.
- Soluble in DMSO (100 mg/mL) and suitable in vivo formulations (≥2.5 mg/mL).
- Storage: pure form -20°C (3 years) or 4°C (2 years).
Broadpharm Azido-PEG5-amine | 516493-93-9 | MFCD16619318 | 1 g
Azido-PEG5-amine | Purity: 98% | Mol Wt: 306.4 | 516493-93-9 | MFCD16619318 | 1 g
Sigma Aldrich Fine Chemicals Biosciences Collagenase/Dispase, 100 mg
Collagenase/Dispase is used for the preparation of cells from a wide variety of different tissues and organs.
Electron Microscopy Sciences Carbowax Polyethylene Glycol, PEG 400 viscous liquid, 25322-68-3, 450ml
Molecular Formula H(OCH2CH2)nOH, Carbowax Polyethylene Glycol is an embedding medium for microscopy and histochemistry.
Medchemexpress LLC Dspe-peg5000-mal ammonium | 474922-22-0 | 98.4% | (C2H4O)nC51H92N1O13P.H3N | 25 MG
DSPE-PEG-Maleimide has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide extends blood circulation time and higher stability for encapsulated agents. DSPE-PEG5000-Mal ammonium contains PEG5000.
- Contains DSPE phospholipid and maleimide for nanostructured lipid carrier preparation
- Extends blood circulation time
- Provides higher stability for encapsulated agents
- Contains PEG5000
Electron Microscopy Sciences Pepsin Reagent Ready To Use 100 ML
Pepsin is used for proteolytic digestion of formalin-fixed paraffin-embedded (FFPE) tissue sections prior to application of antibodies. In IHC most commonly used fixative like formalin mask tissue antigens (cellular, membrane and nuclear) by cross-linking process, this results in poor or no staining in IHC. Pepsin digestion of FFPE tissue section improves accessibility of antibodies to tissue antigens.
Store in temperature of 2-8 degree C. DO NOT FREEZE.
Intended Use: Use as antigen retriever for some antibodies in IHC. Please refer to primary antibody protocol for IHC.
Medchemexpress LLC Mal-PEG4-bis-PEG4-propargyl | 1060.19 g·mol⁻¹ | C49H81N5O20 | 5 MG
Mal-PEG4-bis-PEG4-propargyl is a cleavable eight-unit polyethylene glycol (PEG) linker designed for bioconjugation applications, especially antibody-drug conjugate (ADC) synthesis. It contains a maleimide group for thiol-selective conjugation and a propargyl (alkyne) handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling modular attachment strategies and click chemistry workflows.
- Cleavable eight-unit PEG linker.
- Maleimide group for thiol-selective conjugation.
- Propargyl (alkyne) handle for CuAAC click chemistry.
- Suitable for ADC and general bioconjugation workflows.
- Available in milligram quantities for research use.
Medchemexpress LLC m-PEG4-MS | 130955-37-2 | ≥95.0% | 286.34 | C10H22O7S | 250 MG
m-PEG4-MS is a PEG-based linker used in the synthesis of PROTAC molecules and as a cleavable linker in antibody-drug conjugates (ADCs).
- PEG-based linker for PROTACs and ADCs.
- CAS number: 130955-37-2.
- Purity: ≥95.0%.
- Molecular formula: C10H22O7S.
- Molecular weight: 286.34 g/mol.
- Package size: 250 mg.
eMolecules m-PEG11-alcohol | 114740-40-8 | MFCD06201004 | 10g
Broadpharm | m-PEG11-alcohol | 10g | 550803933 | BP-21575 | 98.000 | 114740-40-8 | MFCD06201004 | 516.625 | C23H48O12
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Medchemexpress LLC Azido-PEG1-C2-acid | 1393330-34-1 | 98.0% | 159.14 | 50MG
Azido-PEG1-C2-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group. This enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules, and it can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group for click chemistry reactions
- Enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions